Melatonin Is Able to Reduce the Apoptotic Liver Changes Induced by Aging Via Inhibition of the Intrinsic Pathway of Apoptosis | Zendy

Virginia Molpeceres | Zendy; José L. Mauriz | Zendy; María Victoria GarcíaMediavilla | Zendy; P. González | Zendy; Juan Pablo Barrio Lera | Zendy; Javier GonzálezGallego | Zendy

Open Access

Melatonin Is Able to Reduce the Apoptotic Liver Changes Induced by Aging Via Inhibition of the Intrinsic Pathway of Apoptosis

Author(s) -

Virginia Molpeceres,

José L. Mauriz,

María Victoria GarcíaMediavilla,

P. González,

Juan Pablo Barrio Lera,

Javier GonzálezGallego

Publication year - 2007

Publication title -

the journals of gerontology series a

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.134

H-Index - 189

eISSN - 1758-535X

pISSN - 1079-5006

DOI - 10.1093/gerona/62.7.687

Subject(s) - melatonin , apoptosis , cytochrome c , reactive oxygen species , medicine , endocrinology , thiobarbituric acid , glutathione , antioxidant , fas ligand , caspase 3 , chemistry , oxidative stress , caspase , programmed cell death , biology , microbiology and biotechnology , biochemistry , lipid peroxidation , enzyme

We examined the effect of daily melatonin supplementation on liver apoptosis induced by aging in rats. Young (3-month-old) and aged (24-month-old) Wistar rats were supplemented daily with melatonin in their drinking water (20 mg/L) for 4 weeks. Aged rats showed increases in the liver concentration of thiobarbituric acid-reactive substances and in the oxidized/reduced glutathione ratio. These increases were accompanied by apoptotic ultrastructural alterations and increases in cytochrome c mitochondrial release, Bax to Bcl-2 relative expression, and activity of caspase-3. No significant changes were observed in Fas-ligand (Fas-L) expression and caspase-8 activity. Melatonin administration was able to abrogate changes detected in aged rats. Data suggest that liver apoptotic cell death is induced by reactive oxygen species, via the intrinsic signalling pathway, and that the antiapoptotic action provided by melatonin is related to its antioxidant effect, with reduction of cytochrome c release by the modulation of Bcl-2 and Bax genes.

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