Reduced Basal Levels and Enhanced LPS Response of IL-6 mRNA in Aged Mice | Zendy

Kavya Sharman | Zendy; Edward Sharman | Zendy; Arezoo Campbell | Zendy; Stephen C. Bondy | Zendy

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Reduced Basal Levels and Enhanced LPS Response of IL-6 mRNA in Aged Mice

Author(s) -

Kavya Sharman,

Edward Sharman,

Arezoo Campbell,

Stephen C. Bondy

Publication year - 2001

Publication title -

the journals of gerontology series a

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.134

H-Index - 189

eISSN - 1758-535X

pISSN - 1079-5006

DOI - 10.1093/gerona/56.12.b520

Subject(s) - basal (medicine) , lipopolysaccharide , senescence , messenger rna , stimulation , biology , cytokine , endocrinology , inflammatory response , interleukin , medicine , interleukin 6 , inflammation , immunology , microbiology and biotechnology , biochemistry , insulin , gene

Senescence is a complex and multifactorial process that may predispose organisms to altered responses to environmental stressors. The cytokine interleukin-6 (IL-6) is expressed by a variety of cells and is one of the earliest mediators of the acute inflammatory response. In this study, the level of IL-6 mRNA in younger (7 months) and old (23 months) mice was determined in the tissue of several organs with or without stimulation with lipopolysaccharide (LPS). Whereas younger animals had a basal expression of IL-6 mRNA in all organs, this was undetectable in the old animals. In contrast, when the mice were injected with LPS, in a majority of the organ tissues there was a robust stimulation of IL-6 mRNA in the old mice whereas the younger animals had a more variable response. These data indicate that the aging process may predispose animals to an exaggerated and potentially harmful inflammatory response.

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