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Proper identification of cell lines is a requirement of rigorous research involving cultured cells. Here we develop an innovative strategy to identify cell lines using transposable element profiles and apply this novel strategy one of the most important model species, Drosophila melanogaster. We clarify the provenance of several Drosophila cell lines and show that loss of heterozygosity affects genome evolution in Drosophila cell culture.

Transposable element profiles reveal cell line identity and loss of heterozygosity in Drosophila cell culture