Transposable element profiles reveal cell line identity and loss of heterozygosity in Drosophila cell culture | Zendy

Shunhua Han | Zendy; Preston J. Basting | Zendy; Guilherme Borges Dias | Zendy; Arthur Luhur | Zendy; Andrew C. Zelhof | Zendy; Casey Bergman | Zendy

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Transposable element profiles reveal cell line identity and loss of heterozygosity in Drosophila cell culture

Author(s) -

Shunhua Han,

Preston J. Basting,

Guilherme Borges Dias,

Arthur Luhur,

Andrew C. Zelhof,

Casey Bergman

Publication year - 2021

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/iyab113

Subject(s) - biology , transposable element , drosophila melanogaster , loss of heterozygosity , retrotransposon , genome , genetics , drosophila (subgenus) , human genome , cell culture , computational biology , allele , gene

Proper identification of cell lines is a requirement of rigorous research involving cultured cells. Here we develop an innovative strategy to identify cell lines using transposable element profiles and apply this novel strategy one of the most important model species, Drosophila melanogaster. We clarify the provenance of several Drosophila cell lines and show that loss of heterozygosity affects genome evolution in Drosophila cell culture.

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