LACK OF GENIC VARIATION IN THE ABUNDANT PROTEINS OF HUMAN KIDNEY | Zendy

Sandra C. Smith | Zendy; R. R. Racine | Zendy; Charles H. Langley | Zendy

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LACK OF GENIC VARIATION IN THE ABUNDANT PROTEINS OF HUMAN KIDNEY

Author(s) -

Sandra C. Smith,

R. R. Racine,

Charles H. Langley

Publication year - 1980

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/96.4.967

Subject(s) - biology , loss of heterozygosity , genetics , variation (astronomy) , genetic variation , phenotype , gel electrophoresis of proteins , microbiology and biotechnology , polyacrylamide gel electrophoresis , gene , allele , biochemistry , enzyme , physics , astrophysics

Abundant proteins of 25 human kidneys were surveyed for genic variation by means of two-dimensional electrophoresis. Eighty-three (83) proteins were scored, and no genic variation was detected. This reduction in genic heterozygosity corroborates results determined with two-dimensional electrophoresis in mice and flies. These results suggest that previous estimates of electrophoretic variation may have been in error because of biased selection of loci.

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