BIOCHEMICAL DIFFERENCES BETWEEN PRODUCTS OF THE Adh LOCUS IN DROSOPHILA | Zendy

John F. McDonald | Zendy; Steven M. Anderson | Zendy; Mauro Santos | Zendy

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BIOCHEMICAL DIFFERENCES BETWEEN PRODUCTS OF THE Adh LOCUS IN DROSOPHILA

Author(s) -

John F. McDonald,

Steven M. Anderson,

Mauro Santos

Publication year - 1980

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/95.4.1013

Subject(s) - biology , alcohol dehydrogenase , locus (genetics) , drosophila melanogaster , genetics , enzyme , genotype , allele , substrate specificity , gene , biochemistry

An analysis of the molecular properties of the major alcohol dehydrogenase (E.C.1.1.1.1) allozyme variants found segregating in natural populations of D. melanogaster is presented. Our results indicate: (1) ADH-S enzyme has generally lower Michaelis-Menten constants than those of ADH-F; (2) ADH-S and ADH-F enzymes display opposite interactions for both co-factor and substrate; and (3) higher levels of ADH are associated with the Adh-fast genotype. The possible adaptive significance of these findings is discussed.

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