MITOTIC RECOMBINATION IN YEAST: ISOLATION AND CHARACTERIZATION OF MUTANTS WITH ENHANCED SPONTANEOUS MITOTIC GENE CONVERSION RATES | Zendy

Daniel H. Maloney | Zendy; Seymour Fogel | Zendy

Open Access

MITOTIC RECOMBINATION IN YEAST: ISOLATION AND CHARACTERIZATION OF MUTANTS WITH ENHANCED SPONTANEOUS MITOTIC GENE CONVERSION RATES

Author(s) -

Daniel H. Maloney,

Seymour Fogel

Publication year - 1980

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/94.4.825

Subject(s) - mitotic crossover , biology , mutant , methyl methanesulfonate , genetics , recombination , mitosis , yeast , locus (genetics) , homologous recombination , genetic recombination , ethyl methanesulfonate , gene conversion , microbiology and biotechnology , ploidy , mutation , gene

Semi-dominant mutants displaying greatly elevated (up to 200-fold above control) levels of spontaneous mitotic recombination have been isolated in a disomic haploid strain of yeast heteroallelic at the arg4 locus. They are designated by the symbol MIC. The mutants variously exhibit associated sensitivity to UV and ionizing radiation and to methyl methanesulfonate, enhanced UV-induced mitotic recombination, and enhanced spontaneous forward mutation rates. Possible enzyme defects and involvement in repair and editing of DNA are discussed. The mutants are expected to simplify the analysis of recombination pathways in yeast.

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