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A mutation has been identified that suppresses the mating and sporulation defects of all mutations in the mating-type loci of S. cereuisiae. This suppressor, sir1-1, restores mating ability to matαl and matα2 mutants and restores sporulation ability to matα2 and mata1 mutants. MATa sir1-1 strains exhibit a polar budding pattern and have reduced sensitivity to α-factor, both properties of a/α diploids. Furthermore, sir1-1 allows MATa/MATa, matα1/matα1, and MATα/MATα strains to sporulate efficiently. All actions of sir1-1 are recessive to SIR1. The ability of sir1-1 to supply all functions necessary for mating and sporulation and its effects in a cells are explained by proposing that sir1-1 allows expression of mating type loci which are ordinarily not expressed. The ability of sir1-1 to suppress the matαl-5 mutation is dependent on the HMa gene, previously identified as required for switching of mating types from a to α. Thus, as predicted by the cassette model, HMa is functionally equivalent to MATα since it supplies functions of MATα. We propose that sir1-1 is defective in a function, Sir ("Silent-information regulator"), whose role may be to regulate expression of HMa and HMα.

A SUPPRESSOR OF MATING-TYPE LOCUS MUTATIONS IN SACCHAROMYCES CEREVISIAE: EVIDENCE FOR AND IDENTIFICATION OF CRYPTIC MATING-TYPE LOCI