GENETIC REGULATION OF MUP PRODUCTION IN RECOMBINANT INBRED MICE | Zendy

Paula Szoka | Zendy; Kenneth Paigen | Zendy

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GENETIC REGULATION OF MUP PRODUCTION IN RECOMBINANT INBRED MICE

Author(s) -

Paula Szoka,

Kenneth Paigen

Publication year - 1979

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/93.1.173

Subject(s) - biology , recombinant dna , locus (genetics) , inbred strain , genetics , gene , phenotype , microbiology and biotechnology

Inbred strains of mice excrete all three major urinary proteins (mups) when induced by testosterone, but differ as to the relative proportions and total levels of each mup present. We have now determined the urinary mup pheno-types before and after testosterone treatment of seven recombinant inbred strains derived from progenitor strains exhibiting different mup phenotypes. The results codirm previous observations indicating that total control of mup protein production is a multigenic process. One locus, Mup-a on chromosome 4, determines the relative mup protein proportions after induction by testoster- one. Mup-a, together with other genetic sites, determines the basal mup proportions. Genes other than Mup-a determine the kinetics of mup induction and total mup excretion.

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