Open AccessTHE Ah LOCUS: BIOCHEMICAL BASIS FOR GENETIC DIFFERENCES IN BRAIN TUMOR FORMATION IN MICE
Author(s) -
Roy C. Levitt,
Jacquelene M. Fysh,
Nancy M. Jensen,
Daniel W. Nebert
Publication year - 1979
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/92.4.1205
Subject(s) - locus (genetics) , biology , allele , genetics , inbred strain , carcinogenesis , gene
Allelic differences at the Ah locus are shown to exist in the mouse brain. This finding probably explains inbred mouse strain differences in polycyclic hydrocarbon tumorigenesis of the brain described more than 35 years ago and may be important in understanding the etiology of genetic differences in certain human intracranial neoplasms.
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