MUTATIONS OF CHINESE HAMSTER SOMATIC CELLS FROM 2-DEOXYGALACTOSE SENSITIVITY TO RESISTANCE | Zendy

JeanMichel Claverie | Zendy; Aristide Comlan de Souza | Zendy; JeanPaul Thirion | Zendy

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MUTATIONS OF CHINESE HAMSTER SOMATIC CELLS FROM 2-DEOXYGALACTOSE SENSITIVITY TO RESISTANCE

Author(s) -

JeanMichel Claverie,

Aristide Comlan de Souza,

JeanPaul Thirion

Publication year - 1979

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/92.2.563

Subject(s) - chinese hamster , somatic cell , biology , genetics , hamster , mutation , galactokinase , microbiology and biotechnology , chinese hamster ovary cell , cell culture , gene , escherichia coli

In Chinese hamster somatic cells, the spontaneous change of phcnotype from 2-deoxygalactose sensitivity to resistance was studied using fluctuation test experiments à la LURIA and DELBRUCK (1943) for four Chinese hamster cell strains derived from V79. The results are consistent with true mutational events. The mutation rates are in the range of 1 to 3.5 × 10-5 per cell per generation. The relationship between the 2-deoxygalactose resistance and the galactokinase markers is discussed.

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