ULTRAVIOLET-INDUCED REVERSION OF cyc1 ALLELES IN RADIATION SENSITIVE STRAINS OF YEAST. II. rev2 MUTANT STRAINS | Zendy

Christopher W. Lawrence | Zendy; Roshan B. Christensen | Zendy

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ULTRAVIOLET-INDUCED REVERSION OF cyc1 ALLELES IN RADIATION SENSITIVE STRAINS OF YEAST. II. rev2 MUTANT STRAINS

Author(s) -

Christopher W. Lawrence,

Roshan B. Christensen

Publication year - 1978

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/90.2.213

Subject(s) - reversion , frameshift mutation , allele , biology , mutant , genetics , missense mutation , saccharomyces cerevisiae , mutation , ultraviolet light , gene , mutagenesis , gene product , yeast , phenotype , microbiology and biotechnology , gene expression , photochemistry , chemistry

The range of specificity of the rev2-1 mutation, an allele that reduces the frequency of ochre revertants induced by UV in Saccharomyces cerevisiae (Lemontt 1971a), has been investigated by examining its influence on the reversion of eleven well-defined and contrasting cyc1 mutations. We have shown, in support of a suggestion of Lemontt (1971a), that the REV2 gene product is concerned only with the reversion of ochre alleles; it plays virtually no role in the reversion of amber, missense or frameshift mutations. We have also shown that its effect is specific and confined to only some highly revertible ochre alleles. The REV2 gene product appears to enhance reversion at these sites by facilitating the conversion of two otherwise nonmutagenic photo-products into a single premutational lesion. UV-induced killing of rev2-1 strains was found to be significantly greater on fermentable rather than on nonfermentable media.

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