EPIDERMIS IS THE SITE OF ACTION OF TABBY (TA) IN THE MOUSE | Zendy

Thomas C. Mayer | Zendy; Margaret C. Green | Zendy

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EPIDERMIS IS THE SITE OF ACTION OF TABBY (TA) IN THE MOUSE

Author(s) -

Thomas C. Mayer,

Margaret C. Green

Publication year - 1978

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/90.1.125

Subject(s) - dermis , epidermis (zoology) , biology , locus (genetics) , anatomy , microbiology and biotechnology , genetics , gene

The site of action of the sex-linked tabby (Ta) locus was analyzed by the technique of dermal-epidermal recombination grafting. Skin components from normal and tabby 14-day embryos were separated, recombined and grown 21 days in testes of histocompatible mice. Grafts of the combinations normal epidermis-normal dermis and normal epidermis-tabby dermis produced predominantly zig-zag hairs. Grafts of the combination tabby epidermis-normal dermis and tabby epidermis-tabby dermis produced hairs with a morphology similar to hairs found in tabby mice. We conclude from these results that the tabby locus acts within the epidermis, and has no effect on the dermis.

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