TESTING HYPOTHESES ABOUT LINKAGE DISEQUILIBRIUM WITH MULTIPLE ALLELES | Zendy

B. S. Weir | Zendy; C. Clark Cockerham | Zendy

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TESTING HYPOTHESES ABOUT LINKAGE DISEQUILIBRIUM WITH MULTIPLE ALLELES

Author(s) -

B. S. Weir,

C. Clark Cockerham

Publication year - 1978

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/88.3.633

Subject(s) - linkage disequilibrium , biology , allele , disequilibrium , genetics , locus (genetics) , linkage (software) , allele frequency , evolutionary biology , haplotype , gene , medicine , ophthalmology

For loci with multiple alleles, hypotheses about linkage disequilibrium may be tested on the complete set of gametic data, or on various collapsed sets of data. Collapsing data into a few alleles at each locus can change the power of the tests, as implied in a recent paper by Zouros, Golding and Mackay (1977). We show that the nature of such changes can be found from properties of the noncentral chi-square distribution, and that the magnitude and direction of these changes depend on the levels of linkage disequilibria, allelic frequencies and degrees of freedom.

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