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Analysis of F2 and backcross animals has confirmed the X-chromosome linkage of Ags, the structural locus for mouse α-galactosidase. The position of Ags has been located in the X chromosome, 9 centimorgans from Mo, and the gene order is centromere-Hq-Bn-Ta-Mo-Ags. A variation in the developmental expression of α-galactosidase activity, inherited as an autosomal trait, has been characterized using recombinant inbred lines of mice. Among certain recombinant inbred lines, the variation appears to segregate as a single major locus.

X-LINKED AND AUTOSOMAL GENES CONTROLLING MOUSE α-GALACTOSIDASE EXPRESSION