X-LINKED AND AUTOSOMAL GENES CONTROLLING MOUSE α-GALACTOSIDASE EXPRESSION | Zendy

Aldons J. Lusis | Zendy; John D. West | Zendy

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X-LINKED AND AUTOSOMAL GENES CONTROLLING MOUSE α-GALACTOSIDASE EXPRESSION

Author(s) -

Aldons J. Lusis,

John D. West

Publication year - 1978

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/88.2.327

Subject(s) - centimorgan , biology , locus (genetics) , genetics , inbred strain , gene , genetic linkage , recombinant dna , centromere , chromosome 4 , microbiology and biotechnology , chromosome , gene mapping

Analysis of F2 and backcross animals has confirmed the X-chromosome linkage of Ags, the structural locus for mouse α-galactosidase. The position of Ags has been located in the X chromosome, 9 centimorgans from Mo, and the gene order is centromere-Hq-Bn-Ta-Mo-Ags. A variation in the developmental expression of α-galactosidase activity, inherited as an autosomal trait, has been characterized using recombinant inbred lines of mice. Among certain recombinant inbred lines, the variation appears to segregate as a single major locus.

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