THE GENETICS OF α-HYDROXYACID OXIDASE AND ALCOHOL DEHYDROGENASE IN THE MOUSE: EVIDENCE FOR MULTIPLE GENE LOCI AND LINKAGE BETWEEN Hao-2 AND Adh-3 | Zendy

Roger S. Holmes | Zendy

Open Access

THE GENETICS OF α-HYDROXYACID OXIDASE AND ALCOHOL DEHYDROGENASE IN THE MOUSE: EVIDENCE FOR MULTIPLE GENE LOCI AND LINKAGE BETWEEN Hao-2 AND Adh-3

Author(s) -

Roger S. Holmes

Publication year - 1977

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/87.4.709

Subject(s) - biology , alcohol dehydrogenase , genetics , isozyme , gene , allele , mendelian inheritance , structural gene , enzyme , genetic linkage , microbiology and biotechnology , biochemistry , mutant

Electrophoretic polymorphisms for stomach alcohol dehydrogenase (ADH-C2) and kidney L-α-hydroxyacid oxidase (HAOX-B4) have been identified in an Asian subspecies of mouse, Mus musculus castaneous. These variants are inherited in a normal Mendelian fashion with two alleles in each case showing codominant expression. The structural gene loci for those enzymes (Adh-3 and Hao-2, respectively) are apparently linked (17.6% recombinants) in this organism, whereas the multiple gene loci for HAOX, Hao-1 (encoding the A4 liver isozyme) and Hao-2, exhibited independent segregation and are unlinked (50% recombinants). Evidence is presented for 3 ADH loci: Adh-1, encoding liver ADH-A2 which exhibits high activity with ethanol (Selander, Hunt and Yang 1969; Adh-2, liver and stomach ADH-B 2 using 2-hexene-1-ol as substrate; and Adh-3, stomach ADH-C 2 using both benzyl alcohol and 2-hexene-1-ol as substrate.

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