MULTILOCUS BEHAVIOR IN RANDOM ENVIRONMENTS. II. LINKAGE DISEQUILIBRIUM IN AN ADDITIVE MODEL | Zendy

John H. Gillespie | Zendy

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MULTILOCUS BEHAVIOR IN RANDOM ENVIRONMENTS. II. LINKAGE DISEQUILIBRIUM IN AN ADDITIVE MODEL

Author(s) -

John H. Gillespie

Publication year - 1977

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/87.3.569

Subject(s) - linkage disequilibrium , disequilibrium , biology , locus (genetics) , genetics , sign (mathematics) , allele , population , linkage (software) , evolutionary biology , statistical physics , statistics , mathematics , mathematical analysis , physics , demography , gene , haplotype , medicine , sociology , ophthalmology

The effect of a stochastic environment on an additive, two-locus model of a diploid population is examined. The appropriate diffusion equation is derived and its asymptotic properties are approximated by an Orstein-Uhlenbeck process. The first and second order moments of this approximating process are given. The mean linkage disequilibrium will be nonzero if the alleles at the different loci are correlated. The sign of the mean disequilibrium is determined by the sign of the correlation.

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