A MODEL OF FUNCTIONAL EPISTASIS AND LINKAGE DISEQUILIBRIUM IN POPULATIONS WITH OVERLAPPING GENERATIONS | Zendy

James T. Giesel | Zendy

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A MODEL OF FUNCTIONAL EPISTASIS AND LINKAGE DISEQUILIBRIUM IN POPULATIONS WITH OVERLAPPING GENERATIONS

Author(s) -

James T. Giesel

Publication year - 1977

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/86.3.679

Subject(s) - linkage disequilibrium , disequilibrium , biology , epistasis , linkage (software) , genetics , evolutionary biology , haplotype , genotype , gene , medicine , ophthalmology

A model of functional epistasis is proposed in which it is assumed that coupling and repulsion genotypes differ in metabolic efficiency and thus in development time and net fecundity. The implications of this model are investigated for iteroparous populations with fluctuating rates of increase. It is found that the fluctuations in rate of increase can lead to large fluctuations in gamete frequency and D, the coefficient of linkage disequilibrium, but that D will almost always have a value of zero at some point during the populations' demographic cycle. Some of the model populations would be expected to be in a state of linkage disequilibrium only fleetingly: others would exhibit D-cycles interpretable as random fluctuation. Implications of the model for interpretations of existing data on linkage disequilibrium among enzyme loci in Drosophila are discussed.

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