LINKAGE DISEQUILIBRIUM FOR TWO X-LINKED GENES IN SARDINIA AND ITS BEARING ON THE STATISTICAL MAPPING OF THE HUMAN X CHROMOSOME | Zendy

G Filippi | Zendy; A Rinaldi | Zendy; R. Palmarino | Zendy; E Seravalli | Zendy; M. Siniscalco | Zendy

Open Access

LINKAGE DISEQUILIBRIUM FOR TWO X-LINKED GENES IN SARDINIA AND ITS BEARING ON THE STATISTICAL MAPPING OF THE HUMAN X CHROMOSOME

Author(s) -

G Filippi,

A Rinaldi,

R. Palmarino,

E Seravalli,

M. Siniscalco

Publication year - 1977

Publication title -

genetics.

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

ISSN - 3049-7094

DOI - 10.1093/genetics/86.1.199

Subject(s) - biology , linkage disequilibrium , genetics , linkage (software) , x chromosome , disequilibrium , genetic linkage , chromosome , gene , evolutionary biology , allele , haplotype , medicine , ophthalmology

The distribution of four X-linked mutants (G6PD, Deutan, Protan and Xg) among lowland and once highly malarial populations of Sardinia discloses a clear-cut example of linkage disequilibrium between two of them (G6PD and Protan). In the same populations the distribution of G6PD-deficiency versus colorblindness of the Deutan type and the Xg blood-group is not significantly different from that expected at equilibrium. These data suggest indirectly that the loci for G6PD and Protan may be nearer to one another than those for G6PD and Deutan.

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