THE CONSEQUENCES OF NULLOSOMY FOR A CHROMOSOMAL REGION AFFECTING CYCLIC AMP PHOSPHODIESTERASE ACTIVITY IN DROSOPHILA | Zendy

John A. Kiger | Zendy

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THE CONSEQUENCES OF NULLOSOMY FOR A CHROMOSOMAL REGION AFFECTING CYCLIC AMP PHOSPHODIESTERASE ACTIVITY IN DROSOPHILA

Author(s) -

John A. Kiger

Publication year - 1977

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/85.4.623

Subject(s) - biology , phosphodiesterase , drosophila melanogaster , genetics , locus (genetics) , gene , gametogenesis , sperm , fertility , microbiology and biotechnology , enzyme , biochemistry , embryogenesis , population , demography , sociology

A study of Drosophila nullosomic for chromomere 3D4 shows that this region of the genome is necessary for male fertility, normal female fertility and normal oogenesis. Males nullosomic for 3D4 lack normal, motile sperm. Females nullosomic for this region exert a maternal influence on their progeny which results in a diversity of imaginal defects. The observation that chromomere 3D4 is the most probable locus for a chromosomal region which affects cAMP phosphodiesterase activity, and which may contain a structural gene for the enzyme, prompts the hypothesis that the diverse physiological effects caused by nullosomy for 3D4 are the result of an aberrant cAMP metabolism.

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