SULFHYDRYL COMPOUNDS IN MELANOCYTES OF YELLOW (Ay/a), NONAGOUTI (a/a), AND AGOUTI (A/A) MICE | Zendy

Donald B. Galbraith | Zendy; Alan M Patrignani | Zendy

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SULFHYDRYL COMPOUNDS IN MELANOCYTES OF YELLOW (Ay/a), NONAGOUTI (a/a), AND AGOUTI (A/A) MICE

Author(s) -

Donald B. Galbraith,

Alan M Patrignani

Publication year - 1976

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/84.3.587

Subject(s) - biology , locus (genetics) , gene , genotype , genetics , metabolism , pigment , microbiology and biotechnology , biochemistry , chemistry , organic chemistry

Cleffmann (1953, 1963a,b) has reported that yellow but not black melanocytes of agouti (A/A) rabbits contained reducing sulfhydryl compounds. We have attempted to repeat Cleffmann's observations in mouse melanocytes of the lethal yellow (Ay/a), nonagouti (a/a) and agouti (A/A) genotypes. Our results contradict those of Cleffmann and reveal that yellow and black melanocytes, regardless of genotype, possess equivalent amounts of histochemically detectable sulfhydryl compounds. These results do not support the hypothesis that agouti-locus genes act by controlling the sulfhydryl metabolism of pigment cells.

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