EXTENSION OF THE LIMITS OF THE XDH STRUCTURAL ELEMENT IN DROSOPHILA MELANOGASTER | Zendy

William M Gelbart | Zendy; Margaret McCarron | Zendy; Arthur Chovnick | Zendy

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EXTENSION OF THE LIMITS OF THE XDH STRUCTURAL ELEMENT IN DROSOPHILA MELANOGASTER

Author(s) -

William M Gelbart,

Margaret McCarron,

Arthur Chovnick

Publication year - 1976

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/84.2.211

Subject(s) - xanthine dehydrogenase , drosophila melanogaster , mutant , complementation , biology , genetics , locus (genetics) , structural gene , enzyme , gene , biochemistry , xanthine oxidase

Experiments expanding the array of mutants affecting the xanthine dehydrogenase (XDH) structural element in Drosophila melanogaster are described. These include rosy eye color mutants which exhibit interallelic complementation, and mutants with normal eye color but lowered levels of XDH. Evidence is presented which argues that these are structural alterations in the enzyme. Recombination experiments were performed using these mutants as well as some electrophoretic variants. The two ends of the rosy locus are marked with mutant sites which are clearly structural in nature; the XDH structural element and the rosy null mutant map are completely concordant. A possible procedure to recover control element mutants is described.

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