Open AccessDYNAMICS OF CORRELATED GENETIC SYSTEMS. I. SELECTION IN THE REGION OF THE GLUED LOCUS OF DROSOPHILA MELANOGASTER
Author(s) -
Michael T. Clegg,
J. F. Kidwell,
Margaret G. Kidwell,
N.J. Daniel
Publication year - 1976
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/83.4.793
Subject(s) - biology , drosophila melanogaster , genetics , locus (genetics) , loss of heterozygosity , phosphoglucomutase , epistasis , selection (genetic algorithm) , melanogaster , background selection , evolutionary biology , allele , gene , enzyme , biochemistry , artificial intelligence , computer science
The dynamical behavior of chromosomal segments undergoing strong selection was investigated in four replicate populations of Drosophila melanogaster. This was accomplished by following the joint behavior of allozyme markers at the loci phosphoglucomutase and esterase C, adjacent to the recessive lethal locus Glued, during and following the course of selection against Glued. The results show strong selection at other loci in the region of the marked segment. Examination of the joint dynamic of the two markers indicates that there must be more than one, and probably several, selected loci in the region under observation, with large epistatic effects. The mode of selection on the segment often results in excess heterozygosity at the markers, but does not appear to be constant in time. It is concluded that the density of selective effects in the region under study is substantial.
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