GENETIC ANALYSIS OF SUSCEPTIBILITY TO ISONIAZID-INDUCED SEIZURES IN MICE | Zendy

Benjamin A. Taylor | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

GENETIC ANALYSIS OF SUSCEPTIBILITY TO ISONIAZID-INDUCED SEIZURES IN MICE

Author(s) -

Benjamin A. Taylor

Publication year - 1976

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/83.2.373

Subject(s) - inbred strain , biology , recombinant dna , genetics , heritability , gene , isoniazid , hybrid , genetic analysis , botany , medicine , tuberculosis , pathology

Four sets of recombinant inbred lines of mice have been used to analyze genetic differences in acute toxicity of the drug, isonicotinic acid hydrazide. Standard inbred strains, their F1 hybrids and recombinant inbred strains were all challenged with a single dose of the drug. The percent mortality of the different groups was analyzed to estimate heritability and the number of genes affecting resistance. The data indicated that resistance factors were dominant, heritability was moderate (.25-.37), and more than one gene was involved in each of four different sets of recombinant inbred lines. Possible approaches for identifying and mapping individual genes affecting resistance are discussed.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research