GENETIC ANALYSIS OF REGULATORY MUTANTS OF ALKALINE PHOSPHATASE OF E. COLI | Zendy

Kenneth N. Kreuzer | Zendy; Charles Pratt | Zendy; Annamaria Torriani | Zendy

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GENETIC ANALYSIS OF REGULATORY MUTANTS OF ALKALINE PHOSPHATASE OF E. COLI

Author(s) -

Kenneth N. Kreuzer,

Charles Pratt,

Annamaria Torriani

Publication year - 1975

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/81.3.459

Subject(s) - biology , alkaline phosphatase , genetics , mutant , mutation , gene , genetic analysis , biochemistry , enzyme

A fine structure map of the phoR region of E. coli, mutations of which affect the rate of alkaline phosphatase synthesis, was constructed by Hfr × F- crosses. Mutations causing three different phenotypes (previously reported as phoRa, phoRb, phoRc (Garen and Echols 1962a, b)) are clustered in three closely linked genetic loci. PhoR mutants of all three types, including the phoRb type not previously tested, are recessive to wild-type phoR+. In addition, phoRa and phoRc complement each other, while phoRa and phoRb do not. Our results support the hypothesis of Morris et al. (1974) that phoRc mutants represent a cistron (phoB) different from phoR.

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