A FINE STRUCTURE MAP OF THE SALMONELLA HISTIDINE OPERATOR-PROMOTER | Zendy

Bert Ely | Zendy; D. B. Fankhauser | Zendy; Philip Hartman | Zendy

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A FINE STRUCTURE MAP OF THE SALMONELLA HISTIDINE OPERATOR-PROMOTER

Author(s) -

Bert Ely,

D. B. Fankhauser,

Philip Hartman

Publication year - 1974

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/78.2.607

Subject(s) - operon , biology , genetics , recombination , histidine , gal operon , point mutation , operator (biology) , trp operon , salmonella , mutation , gene , microbiology and biotechnology , escherichia coli , gene expression , repressor , amino acid , bacteria

Over 100 regulatory mutations linked to the histidine (his) operon of S. typhimurium have been isolated. They all map in a region estimated to be several hundred base pairs in length located at one end of the his operon ("the hisO region"). The mutations are located at sixteen recombinationally separable sites or are deletions encompassing several sites. Data obtained from pairs of reciprocal three-point tests show that "constitutive" (high enzyme levels) and "promoter-like" (low enzyme levels) hisO mutations are interspersed on the genetic map. In a few crosses, recombination was not observed to occur between markers shown to occupy different sites based on behavior in other recombination tests.

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