SELECTION FOR HIGH MUTATION RATES IN CHEMOSTATS | Zendy

Edward C. Cox | Zendy; Thomas C. Gibson | Zendy

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SELECTION FOR HIGH MUTATION RATES IN CHEMOSTATS

Author(s) -

Edward C. Cox,

Thomas C. Gibson

Publication year - 1974

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/77.2.169

Subject(s) - chemostat , biology , genetics , selection (genetic algorithm) , mutant , mutation , escherichia coli , mutation rate , population , competition (biology) , genetic fitness , gene , bacteria , ecology , demography , artificial intelligence , sociology , computer science

Competition experiments in chemostats show that mutator populations of Escherichia coli are more fit than wild type. The increased fitness can be explained by the appearance of new mutants better adapted to the chemostat environment. Fitness values vary between chemostats and are strongly correlated (P < 0.001) with fluctuations in population density.

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