THE GENETICS OF CAENORHABDITIS ELEGANS | Zendy

Sydney Brenner | Zendy

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THE GENETICS OF CAENORHABDITIS ELEGANS

Author(s) -

Sydney Brenner

Publication year - 1974

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/77.1.71

Subject(s) - biology , caenorhabditis elegans , complementation , genetics , mutant , caenorhabditis , mutation , gene , drosophila (subgenus) , chromosome

Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm. About 300 EMS-induced mutants affecting behavior and morphology have been characterized and about one hundred genes have been defined. Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C.elegans are large.

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