Open AccessGENETIC ANALYSIS OF THE ACTIVE SITES OF lac REPRESSOR
Author(s) -
Magnus Pfahl,
Christel Stockter,
Bruno Gronenborn
Publication year - 1974
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/76.4.669
Subject(s) - genetics , biology , repressor , lac repressor , gene , deletion mapping , mutant , mutation , gene cluster , gene expression , chromosome
Selection methods for the isolation of i -d and i s mutants are described. Two hundred and forty-seven i -d and 98 i s mutations have been localized by deletion mapping. All i -d mutations map in the region of the i gene, which codes for the aminoterminal part of the lac repressor, whereas i s mutations map in the middle of the i gene and at the proximal end of the i -d cluster.
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