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INTERACTION BETWEEN NATURAL SELECTION FOR HETEROZYGOTES AND DIRECTIONAL SELECTION
Author(s) -
Margrith W. Verghese
Publication year - 1974
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/76.1.163
Subject(s) - selection (genetic algorithm) , natural selection , biology , directional selection , genetics , stabilizing selection , allele , trait , heterozygote advantage , evolutionary biology , disruptive selection , genetic variation , gene , computer science , machine learning , programming language
When directional selection for an additively inherited trait is opposed by natural selection favoring heterozygous genotypes a selection plateau may be reached where genetic variance is present. The amount of response when this plateau is reached is a simple function of the selection response in the first generation and the intensity of natural selection. When selection is practiced in small populations, the sizes of the initial equilibrium gene frequencies are at least as important as the intensity of natural selection in determining the probability of fixing desirable alleles.

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