SELECTION IN COMPLEX GENETIC SYSTEMS I. THE SYMMETRIC EQUILIBRIA OF THE THREE-LOCUS SYMMETRIC VIABILITY MODEL | Zendy

Marcus W. Feldman | Zendy; Ian R. Franklin | Zendy; Glenys Thomson | Zendy

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SELECTION IN COMPLEX GENETIC SYSTEMS I. THE SYMMETRIC EQUILIBRIA OF THE THREE-LOCUS SYMMETRIC VIABILITY MODEL

Author(s) -

Marcus W. Feldman,

Ian R. Franklin,

Glenys Thomson

Publication year - 1974

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/76.1.135

Subject(s) - linkage disequilibrium , locus (genetics) , biology , pairwise comparison , genetics , linkage (software) , genetic linkage , selection (genetic algorithm) , mathematics , haplotype , allele , statistics , computer science , gene , artificial intelligence

The symmetric equilibria of the three-locus symmetric viability model are determined and their stability analyzed. For tight linkage there may be four stable equilibria, each characterized by having one pair of complementary chromosomes in high frequencies, with all others low. For looser linkage the only stable symmetric equilibrium is that with complete linkage equilibrium. For intermediate recombination values both types of equilibria may be stable. A new class of equilibria with all pairwise linkage disequilibria zero, but with third order linkage disequilibrium, has been discovered. It may be stable for tight linkage.

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