KINETICS OF GENETIC RECOMBINATION IN ESCHERICHIA COLI K-12: COMPETITION BETWEEN GENETIC INTEGRATION AND DEGRADATION | Zendy

Jonathan T. Ou | Zendy; Thomas H. Wood | Zendy

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KINETICS OF GENETIC RECOMBINATION IN ESCHERICHIA COLI K-12: COMPETITION BETWEEN GENETIC INTEGRATION AND DEGRADATION

Author(s) -

Jonathan T. Ou,

Thomas H. Wood

Publication year - 1973

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/75.4.579

Subject(s) - recombination , biology , genetics , escherichia coli , chloramphenicol , zygote , competition (biology) , genetic recombination , mutation , chromosome , kinetics , gene , antibiotics , ecology , embryogenesis , physics , quantum mechanics

The effect of shifting zygotes from a rich medium into a poor medium (shift-down) on the frequency of recombination has been examined; our results suggest that protein syntheses other than those required for growth may be involved. Experiments with chloramphenicol support this notion, and further suggest that there is a competition between genetic integration and degradation in the recipient cells. By inhibiting protein synthesis one can shift the competition in favor of either integration or segregation, depending on the physiological state of the zygotes. By calculating the time required for segregation as one generation, we conclude that the recombination chromosome is homozygous at the time of integration.

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