A QUANTITATIVE ANALYSIS OF THE GENETICS OF RESTING BLOOD LACTIC ACID LEVELS IN MICE | Zendy

Patricia L Hatchell | Zendy; James W. MacInnes | Zendy

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A QUANTITATIVE ANALYSIS OF THE GENETICS OF RESTING BLOOD LACTIC ACID LEVELS IN MICE

Author(s) -

Patricia L Hatchell,

James W. MacInnes

Publication year - 1973

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/75.1.191

Subject(s) - biology , dominance (genetics) , heterosis , inbred strain , genetics , genotype , lactic acid , phenotype , gene , hybrid , bacteria , botany

Resting blood lactate levels were measured in inbred mouse strains, their F1, and several of their segregating generations to determine whether the level of lactic acid is influenced by genetic factors. The inbred strains in each of the two sets used differed significantly from one another for this character. Only one strain showed a significant sex difference. The data could not be fully analyzed because of the failure to fulfill Mather's first criterion for an adequate scale. Nonallelic interactions, in particular, additive x dominance and dominance x dominance, were found to influence the generation means. Genotype x environment interaction was detected and eliminated by log transformation. Negative heterosis was exhibited by all but one noninbred generation.—The data suggest that genes influencing the character are dispersed between the parental lines and that interactions are predominantly of the duplicate kind. A buffering system by which lactate levels are kept at a minimum is proposed.

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