GENETIC RELATIONSHIP BETWEEN ARYL HYDROCARBON HYDROXYLASE INDUCIBILITY AND CHEMICAL CARCINOGEN INDUCED SKIN ULCERATION IN MICE | Zendy

Thomas K. H. Chang | Zendy; John J. Hutton | Zendy; Benjamin A. Taylor | Zendy

Open Access

GENETIC RELATIONSHIP BETWEEN ARYL HYDROCARBON HYDROXYLASE INDUCIBILITY AND CHEMICAL CARCINOGEN INDUCED SKIN ULCERATION IN MICE

Author(s) -

Thomas K. H. Chang,

John J. Hutton,

Benjamin A. Taylor

Publication year - 1973

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/74.4.655

Subject(s) - biology , inbred strain , carcinogen , allele , strain (injury) , genetics , aryl , enzyme , gene , biochemistry , chemistry , organic chemistry , anatomy , alkyl

Inbred strains of mice show differential skin inflammatory reactivity following the topical application of polycyclic hydrocarbons. Strains also differ in the extent to which hepatic aryl hydrocarbon hydroxylase activity is induced by these compounds. Differential inflammatory response and hydroxylase inducibility are genetically controlled by alleles at the In and Ahh loci, respectively. Genetic analyses and strain surveys indicate that the In and Ahh loci are identical, or very closely linked.

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