Open AccessCompositional Biases and Polyalanine Runs in Humans
Author(s) -
Julie Cocquet,
Elfride De Baere,
Sandrine Caburet,
Reiner A. Veitia
Publication year - 2003
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/165.3.1613
Subject(s) - orfs , biology , open reading frame , genetics , histidine , codon usage bias , amino acid , gc content , glycine , alanine , start codon , gene , peptide sequence , genome , base sequence
Human proteins containing polyalanine tracts tend to have runs of other amino acids and their open reading frames (ORFs) display a biased codon usage. Their alanine, glycine, proline, and histidine content strongly correlates with the GC content of the third codon base, suggesting that the compositional specificity of these proteins is dictated to a great extent by the evolution of their ORFs.