The Extent of Linkage Disequilibrium and Haplotype Sharing Around a Polymorphic Site | Zendy

Hideki Innan | Zendy; Magnus Nordborg | Zendy

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The Extent of Linkage Disequilibrium and Haplotype Sharing Around a Polymorphic Site

Author(s) -

Hideki Innan,

Magnus Nordborg

Publication year - 2003

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/165.1.437

Subject(s) - haplotype , linkage disequilibrium , biology , recombination , genetics , disequilibrium , linkage (software) , complete linkage , coalescent theory , selection (genetic algorithm) , evolutionary biology , allele , gene , genotype , phylogenetic tree , single nucleotide polymorphism , computer science , medicine , ophthalmology , artificial intelligence

Various expressions related to the length of a conserved haplotype around a polymorphism of known frequency are derived. We obtain exact expressions for the probability that no recombination has occurred in a sample or subsample. We obtain an approximation for the probability that no recombination that could give rise to a detectable recombination event (through the four-gamete test) has occurred. The probabilities can be used to obtain approximate distributions for the length of variously defined haplotypes around a polymorphic site. The implications of our results for data analysis, and in particular for detecting selection, are discussed.

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