False Discovery Rate in Linkage and Association Genome Screens for Complex Disorders | Zendy

Chiara Sabatti | Zendy; Susan K. Service | Zendy; Nelson B. Freimer | Zendy

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False Discovery Rate in Linkage and Association Genome Screens for Complex Disorders

Author(s) -

Chiara Sabatti,

Susan K. Service,

Nelson B. Freimer

Publication year - 2003

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/164.2.829

Subject(s) - biology , linkage (software) , genetics , genome , genetic linkage , computational biology , association (psychology) , genome wide association study , genetic association , gene , genotype , single nucleotide polymorphism , philosophy , epistemology

We explore the implications of the false discovery rate (FDR) controlling procedure in disease gene mapping. With the aid of simulations, we show how, under models commonly used, the simple step-down procedure introduced by Benjamini and Hochberg controls the FDR for the dependent tests on which linkage and association genome screens are based. This adaptive multiple comparison procedure may offer an important tool for mapping susceptibility genes for complex diseases.

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