The Coalescent and Infinite-Site Model of a Small Multigene Family | Zendy

Hideki Innan | Zendy

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The Coalescent and Infinite-Site Model of a Small Multigene Family

Author(s) -

Hideki Innan

Publication year - 2003

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/163.2.803

Subject(s) - coalescent theory , biology , genetics , gene , linkage disequilibrium , evolutionary biology , allele , haplotype , phylogenetic tree

The infinite-site model of a small multigene family with two duplicated genes is studied. The expectations of the amounts of nucleotide variation within and between two genes and linkage disequilibrium are obtained, and a coalescent-based method for simulating patterns of polymorphism in a small multigene family is developed. The pattern of DNA variation is much more complicated than that in a single-copy gene, which can be simulated by the standard coalescent. Using the coalescent simulation of duplicated genes, the applicability of statistical tests of neutrality to multigene families is considered.

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