Context Dependence of Meiotic Recombination Hotspots in Yeast: The Relationship Between Recombination Activity of a Reporter Construct and Base Composition | Zendy

Thomas D. Petes | Zendy; Jason D. Merker | Zendy

Open Access

Context Dependence of Meiotic Recombination Hotspots in Yeast: The Relationship Between Recombination Activity of a Reporter Construct and Base Composition

Author(s) -

Thomas D. Petes,

Jason D. Merker

Publication year - 2002

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/162.4.2049

Subject(s) - recombination , biology , saccharomyces cerevisiae , genetics , meiosis , homologous recombination , plasmid , flp frt recombination , context (archaeology) , genetic recombination , dna , yeast , gene , paleontology

Borde and colleagues reported that a reporter plasmid inserted at different genomic locations in Saccharomyces cerevisiae had different levels of meiotic recombination activity. We show that the level of recombination activity is very significantly correlated with the GC content of DNA sequences flanking the insertion.

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