Genomic Effects of Nucleotide Substitutions in Drosophila simulans | Zendy

Andrew D. Kern | Zendy; Corbin D. Jones | Zendy; David J. Begun | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Genomic Effects of Nucleotide Substitutions in Drosophila simulans

Author(s) -

Andrew D. Kern,

Corbin D. Jones,

David J. Begun

Publication year - 2002

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/162.4.1753

Subject(s) - biology , genetics , fixation (population genetics) , background selection , directional selection , drosophila (subgenus) , selection (genetic algorithm) , evolutionary biology , recombination , single nucleotide polymorphism , lineage (genetic) , neutral theory of molecular evolution , negative selection , variation (astronomy) , genetic variation , gene , genome , genotype , artificial intelligence , computer science , physics , astrophysics

Selective fixation of beneficial mutations reduces levels of linked, neutral variation. The magnitude of this “hitchhiking effect” is determined by the strength of selection and the recombination rate between selected and neutral sites. Thus, depending on the values of these parameters and the frequency with which directional selection occurs, the genomic scale over which directional selection reduces levels of linked variation may vary widely. Here we present a permutation-based analysis of nucleotide polymorphisms and fixations in Drosophila simulans. We show evidence of pervasive small-scale hitchhiking effects in this lineage. Furthermore, our results reveal that different types of fixations are associated with different levels of linked variation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research