The Use of Genetic Markers to Measure Genomic Response to Selection in Livestock | Zendy

Luis GomezRaya | Zendy; Hanne Gro Olsen | Zendy; Frode Lingaas | Zendy; Helge Klungland | Zendy; Dag Inge Våge | Zendy; Ingrid Olsaker | Zendy; Seblewengel Bekele Talle | Zendy; Monica Aasland | Zendy; Sigbjørn Lien | Zendy

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The Use of Genetic Markers to Measure Genomic Response to Selection in Livestock

Author(s) -

Luis GomezRaya,

Hanne Gro Olsen,

Frode Lingaas,

Helge Klungland,

Dag Inge Våge,

Ingrid Olsaker,

Seblewengel Bekele Talle,

Monica Aasland,

Sigbjørn Lien

Publication year - 2002

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/162.3.1381

Subject(s) - biology , sire , genetics , selection (genetic algorithm) , genetic marker , allele , genome , quantitative trait locus , natural selection , gene , zoology , artificial intelligence , computer science

A method to measure genomic response to natural and artificial selection by means of genetic markers in livestock is proposed. Genomic response through several levels of selection was measured using sequential testing for distorted segregation of alleles among selected and nonselected sons, single-sperm typing, and a test with records for growth performance. Statistical power at a significance level of 0.05 was >0.5 for a marker linked to a QTL with recombination fractions 0, 0.10, and 0.20 for detecting genomic responses for gene effects of 0.6, 0.7, and 1.0 phenotypic standard deviations, respectively. Genomic response to artificial selection in six commercial bull sire families comprising 285 half-sib sons selected for growth performance was measured using 282 genetic markers evenly distributed over the cattle genome. A genome-wide test using selected sons was significant (P < 0.001), indicating that selection induces changes in the genetic makeup of commercial cattle populations. Markers located in chromosomes 6, 10, and 16 identified regions in those chromosomes that are changing due to artificial selection as revealed by the association of records of performance with alleles at specific markers. Either natural selection or genetic drift may cause the observed genomic response for markers in chromosomes 1, 7, and 17.

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