Homozygosity and Linkage Disequilibrium | Zendy

Chiara Sabatti | Zendy; Neil Risch | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Homozygosity and Linkage Disequilibrium

Author(s) -

Chiara Sabatti,

Neil Risch

Publication year - 2002

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/160.4.1707

Subject(s) - linkage disequilibrium , disequilibrium , biology , loss of heterozygosity , genetics , haplotype , linkage (software) , runs of homozygosity , evolutionary biology , allele , genotype , gene , single nucleotide polymorphism , medicine , ophthalmology

We illustrate how homozygosity of haplotypes can be used to measure the level of disequilibrium between two or more markers. An excess of either homozygosity or heterozygosity signals a departure from the gametic phase equilibrium: We describe the specific form of dependence that is associated with high (low) homozygosity and derive various linkage disequilibrium measures. They feature a clear biological interpretation, can be used to construct tests, and are standardized to allow comparison across loci and populations. They are particularly advantageous to measure linkage disequilibrium between highly polymorphic markers.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research