Multiple Subunits of the Caenorhabditis elegans Anaphase-Promoting Complex Are Required for Chromosome Segregation During Meiosis I | Zendy

Edward S. Davis | Zendy; Lucia Wille | Zendy; Barry A. Chestnut | Zendy; Penny L. Sadler | Zendy; Diane C. Shakes | Zendy; Andy Golden | Zendy

Open Access

Multiple Subunits of the Caenorhabditis elegans Anaphase-Promoting Complex Are Required for Chromosome Segregation During Meiosis I

Author(s) -

Edward S. Davis,

Lucia Wille,

Barry A. Chestnut,

Penny L. Sadler,

Diane C. Shakes,

Andy Golden

Publication year - 2002

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/160.2.805

Subject(s) - biology , meiosis , genetics , caenorhabditis elegans , anaphase , sister chromatids , homologous chromosome , chromosome segregation , establishment of sister chromatid cohesion , chromosomal crossover , cohesin , chromatid , synaptonemal complex , separase , chromosome , gene

Two genes, originally identified in genetic screens for Caenorhabditis elegans mutants that arrest in metaphase of meiosis I, prove to encode subunits of the anaphase-promoting complex or cyclosome (APC/C). RNA interference studies reveal that these and other APC/C subunits are essential for the segregation of chromosomal homologs during meiosis I. Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion.

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