Open AccessComparative Analysis of the Human Dystrophin and Utrophin Gene Structures
Author(s) -
Uberto Pozzoli,
Manuela Sironi,
Rachele Cagliani,
Giacomo P. Comi,
Alessandra Bardoni,
Nereo Bresolin
Publication year - 2002
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1093/genetics/160.2.793
Subject(s) - utrophin , dystrophin , biology , genetics , gene , computational biology
We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes.
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