Mapping Quantitative Trait Loci Using Generalized Estimating Equations | Zendy

Christoph Lange | Zendy; John C. Whittaker | Zendy

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Mapping Quantitative Trait Loci Using Generalized Estimating Equations

Author(s) -

Christoph Lange,

John C. Whittaker

Publication year - 2001

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/159.3.1325

Subject(s) - quantitative trait locus , gee , generalized estimating equation , biology , family based qtl mapping , trait , inclusive composite interval mapping , genetics , r package , computational biology , statistics , mathematics , gene mapping , computer science , gene , chromosome , programming language

A number of statistical methods are now available to map quantitative trait loci (QTL) relative to markers. However, no existing methodology can simultaneously map QTL for multiple nonnormal traits. In this article we rectify this deficiency by developing a QTL-mapping approach based on generalized estimating equations (GEE). Simulation experiments are used to illustrate the application of the GEE-based approach.

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