Population Admixture May Appear to Mask, Change or Reverse Genetic Effects of Genes Underlying Complex Traits | Zendy

HongWen Deng | Zendy

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Population Admixture May Appear to Mask, Change or Reverse Genetic Effects of Genes Underlying Complex Traits

Author(s) -

HongWen Deng

Publication year - 2001

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/159.3.1319

Subject(s) - biology , genetics , population , gene , identification (biology) , evolutionary biology , genetic association , genetic architecture , genetic model , polygene , quantitative trait locus , single nucleotide polymorphism , genotype , ecology , demography , sociology

Association studies using random population samples are increasingly being applied in the identification and inference of genetic effects of genes underlying complex traits. It is well recognized that population admixture may yield false-positive identification of genetic effects for complex traits. However, it is less well appreciated that population admixture can appear to mask, change, or reverse true genetic effects for genes underlying complex traits. By employing a simple population genetics model, we explore the effects and the conditions of population admixture in masking, changing, or even reversing true genetic effects of genes underlying complex traits.

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