The Age of a Unique Event Polymorphism | Zendy

Lada Markovtsova | Zendy; Paul Marjoram | Zendy; Simon Tavaré | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The Age of a Unique Event Polymorphism

Author(s) -

Lada Markovtsova,

Paul Marjoram,

Simon Tavaré

Publication year - 2000

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/156.1.401

Subject(s) - biology , genetics , mutation , mitochondrial dna , sequence (biology) , population , markov chain , gene , statistics , mathematics , demography , sociology

We develop a Markov chain Monte Carlo approach for estimating the distribution of the age of a mutation that is assumed to have arisen just once in the history of the population of interest. We assume that in addition to the presence or absence of this mutation in a sample of chromosomes, we have DNA sequence data from a region completely linked to the mutant site. We apply our method to a mitochondrial data set in which the DNA sequence data come from hypervariable region I and the mutation of interest is the 9-bp region V deletion.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research