Adaptive Evolution of Relish, a Drosophila NF-κB/IκB Protein | Zendy

David J. Begun | Zendy; Penn Whitley | Zendy

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Adaptive Evolution of Relish, a Drosophila NF-κB/IκB Protein

Author(s) -

David J. Begun,

Penn Whitley

Publication year - 2000

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/154.3.1231

Subject(s) - biology , drosophila melanogaster , drosophila (subgenus) , genetics , acquired immune system , innate immune system , melanogaster , population , nf κb , evolutionary biology , immune system , gene , microbiology and biotechnology , signal transduction , demography , sociology

NF-κB and IκB proteins have central roles in regulation of inflammation and innate immunity in mammals. Homologues of these proteins also play an important role in regulation of the Drosophila immune response. Here we present a molecular population genetic analysis of Relish, a Drosophila NF-κB/IκB protein, in Drosophila simulans and D. melanogaster. We find strong evidence for adaptive protein evolution in D. simulans, but not in D. melanogaster. The adaptive evolution appears to be restricted to the IκB domain. A possible explanation for these results is that Relish is a site of evolutionary conflict between flies and their microbial pathogens.

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