HMR-I Is an Origin of Replication and a Silencer in Saccharomyces cerevisiae | Zendy

David H. Rivier | Zendy; Joanne Ekena | Zendy; Jasper Rine | Zendy

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HMR-I Is an Origin of Replication and a Silencer in Saccharomyces cerevisiae

Author(s) -

David H. Rivier,

Joanne Ekena,

Jasper Rine

Publication year - 1999

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/151.2.521

Subject(s) - silencer , biology , gene silencing , saccharomyces cerevisiae , genetics , origin of replication , locus (genetics) , plasmid , replication (statistics) , dna replication , replication timing , function (biology) , gene , virology , mechanical engineering , engineering , inlet

There appear to be fundamental differences between the properties of the silencers at HML and HMR, with some being origins of replication and others not. Moreover, past studies have suggested that HMR-I's role in silencing may be restricted to plasmid contexts. This study established that HMR-I, like HMR-E and unlike either HML silencer, is an origin of replication. Moreover, both HMR-E and HMR-I contribute to silencing of a chromosomal HMR locus. In addition, we found that Abf1p plays no unique role in silencer function.

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