Embryonic Lethality and Tumorigenesis Caused by Segmental Aneuploidy on Mouse Chromosome 11 | Zendy

Pentao Liu | Zendy; Heju Zhang | Zendy; Andrew McLellan | Zendy; Hannes Vogel | Zendy; Allan Bradley | Zendy

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Embryonic Lethality and Tumorigenesis Caused by Segmental Aneuploidy on Mouse Chromosome 11

Author(s) -

Pentao Liu,

Heju Zhang,

Andrew McLellan,

Hannes Vogel,

Allan Bradley

Publication year - 1998

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/150.3.1155

Subject(s) - biology , aneuploidy , embryonic stem cell , gene duplication , chromosome engineering , germline , genetics , carcinogenesis , chromosome , microbiology and biotechnology , gene

Chromosome engineering in mice enables the construction of models of human chromosomal diseases and provides key reagents for genetic studies. To begin to define functional information for a small portion of chromosome 11, deficiencies, duplications, and inversions were constructed in embryonic stem cells with sizes ranging from 1 Mb to 22 cM. Two deficiencies and three duplications were established in the mouse germline. Mice with a 1-Mb duplication developed corneal hyperplasia and thymic tumors, while two different 3- to 4-cM deficiencies were embryonically lethal in heterozygous mice. A duplication corresponding to one of these two deficiencies was able to rescue its haplolethality.

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