Coalescent Theory for a Partially Selfing Population | Zendy

Yun-Xin Fu | Zendy

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Coalescent Theory for a Partially Selfing Population

Author(s) -

Yun-Xin Fu

Publication year - 1997

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1093/genetics/146.4.1489

Subject(s) - coalescent theory , selfing , biology , mutation rate , population , estimator , genetics , variance (accounting) , effective population size , sample (material) , statistics , ploidy , sampling (signal processing) , sequence (biology) , evolutionary biology , mathematics , gene , genetic variation , phylogenetic tree , computer science , demography , physics , detector , accounting , thermodynamics , sociology , business , telecommunications

A coalescent theory for a sample of DNA sequences from a partially selfing diploid population and an algorithm for simulating such samples are developed in this article. Approximate formulas are given for the expectation and the variance of the number of segregating sites in a sample of k sequences from n individuals. Several new estimators of the important parameters θ = 4Nμ and the selfing rate s, where N and μ are, respectively, the effective population size and the mutation rate per sequence per generation, are proposed and their sampling properties are studied.

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